Steatosis in chronic hepatitis C: Relative contributions of obesity, diabetes mellitus, and alcohol

摘要: Steatosis has emerged as a histologic finding of importance to the progression hepatitis C virus (HCV)-associated liver disease. However, most studies HCV-associated steatosis have excluded alcohol drinkers and individuals with diabetes thus not addressed relative contribution known causes injury in To address this issue, we studied 297 consecutive patients HCV who met inclusion criteria. Alcohol consumption, demographics, serologic tests were correlated degrees fibrosis on biopsy. Liver biopsy specimens also examined for evidence significant or nonalcoholic steatohepatitis (NASH) injury. In univariate analysis, type 2 mellitus (P = .005) body mass index (BMI) .0001) but intensity intake (in grams per day). multivariate BMI .0002) genotype 3a infection .02) independent predictors steatosis. When risk factors NASH excluded, was only predictor .04) inflammation < scores fibrosis. Significant found 6% specimens. conclusion, is associated NASH, particularly obesity, rather than consumption. (HEPATOLOGY 2002;36:729-736.)