Diamidines for human African trypanosomiasis.
作者： Richard R Tidwell , David W Boykin , Harry P De Koning , John K Thuita , Claudia N Generaux
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摘要: Aromatic diamidines are potent trypanocides. Pentamidine, a diamidine, has been used for more than 60 years to treat human African trypanosomiasis (HAT); however, the drug must be administered parenterally and is active against first-stage HAT only, prior parasites causing neurological deterioration through invasion of CNS. A major research effort design novel led development orally prodrugs and, remarkably, new generation compounds that can penetrate In this review, progress in treatment discussed
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