作者: Kevin D. Wright , Alexander Staruschenko , Andrey Sorokin
DOI: 10.1152/AJPRENAL.00414.2017
关键词:
摘要: p66Shc is one of the three adaptor proteins encoded by Shc1 gene, which are expressed in many organs, including kidney. Recent studies shed new light on several key questions concerning signaling mechanisms mediated p66Shc. The central goal this review article to summarize recent findings and role it plays kidney physiology pathology. This provides a various whereby has been shown function within through wide range actions. mitochondrial cytoplasmic p66Shc, as relates production reactive oxygen species (ROS) renal pathologies, further discussed.