Hemorragia subaracnoidea, isquemia cerebral y endotelina-1

摘要: SUBARACHNOID HEMORRHAGE,CEREBRAL ISCHEMIA AND ENDOTHELIN-1Summary. Introduction. Cerebral vasospasm is involved in the development of delayed ischemic lesions patients with subarach-noid hemorrhage. We developed an integral theoretical model to explain pathophysiology cerebral vasospasm, whichendothelin-1 has a pivotal role both and neurological deficits (DIND) .Objective. The objective this study analyze relationship between temporal profile plasma endothelin-1 levels thedevelopment DIND. Patients methods. analyzed sequentially in17 aneurysmatic subarachnoid All had complete clinical neuroradiological studies.Patients were classified according Fisher’s score. Results. (4 males 13 females, aged 48.1 ± 20.3 years) goodclinical condition (Hunt-Hess 10). Two weeks after bleeding, higher than healt hyvolunteers (p= 0.024). who DIND 0,034) different evolution(p= 0.0146) without There significant correlation 0,02) basal ndGOS Multiple regression analysis shows dependence score(p= 0.0195), 0.0095), GOS score 0,0319). Logistic finds predictiverelation for (overall predicted= 74.24%; p= 0.014 8).Conclusions. Plasma are increased hemorrhage associated [REV NEUROL 2000; 30: 27-34] [http://www.revneurol.com/3001/i010027.pdf]Key words. vasospasm. Delayed deficit. Endothelin-1. Pathophysiology. Subarachnoid