Targeting Signal Transduction Pathways in Hematopoietic Disorders

摘要: Hematopoiesis is the process during which pluripotent stem cells give rise to lineage committed progenitors that differentiate into mature erythroid, myeloid, and lymphoid cells. This a finely regulated required for optimal maintenance of peripheral blood counts. Alterations in hematopoiesis can lead variety bone marrow failure syndromes hematological malignancies. Treatment these diseases requires detailed study pathogenic mechanisms hematopoietic failure.