A conserved inhibitory mechanism of a lycorine derivative against enterovirus and hepatitis C virus

Yu Guo, Wenming Wang, Yuna Sun, Chao Ma, Xu Wang, Xin Wang, Pi Liu, Shu Shen, Baobin Li, Jianping Lin, Fei Deng, Hualin Wang, Zhiyong Lou, Crystal Structure of the Core Region of Hantavirus Nucleocapsid Protein Reveals the Mechanism for Ribonucleoprotein Complex Formation Journal of Virology. ,vol. 90, pp. 1048- 1061 ,(2016) , 10.1128/JVI.02523-15

Lin Cao, Shouhai Zhu, Yaxin Wang, Zhiyong Lou, Yuna Sun, A comprehensive procedure for antiviral inhibitor discovery using EV71 as an example Biophysics Reports. ,vol. 1, pp. 81- 89 ,(2015) , 10.1007/S41048-015-0006-Z

Yangyang Zhai, Xiangshuai Zhao, Zhengjie Cui, Man Wang, Yaxin Wang, Linfeng Li, Qi Sun, Xi Yang, Debin Zeng, Ying Liu, Yuna Sun, Zhiyong Lou, Luqing Shang, Zheng Yin, Cyanohydrin as an Anchoring Group for Potent and Selective Inhibitors of Enterovirus 71 3C Protease Journal of Medicinal Chemistry. ,vol. 58, pp. 9414- 9420 ,(2015) , 10.1021/ACS.JMEDCHEM.5B01013

Shipman C, Prichard Mn, Analysis of combinations of antiviral drugs and design of effective multidrug therapies. Antiviral Therapy. ,vol. 1, pp. 9- 20 ,(1996)

Ching-Sheng Hsu, Sofosbuvir for previously untreated chronic hepatitis C infection. The New England Journal of Medicine. ,vol. 369, pp. 678- ,(2013) , 10.1056/NEJMC1307641#SA1

Stanislas Pol, Anaïs Vallet-Pichard, Marion Corouge, Vincent O. Mallet, Hepatitis C: Epidemiology, Diagnosis, Natural History and Therapy Contributions To Nephrology. ,vol. 176, pp. 1- 9 ,(2012) , 10.1159/000332374

A. Jimenez, A. Santos, G. Alonso, D. Vazquez, Inhibitors of protein synthesis in eukaryotic cells: Comparative effects of some Amaryllidaceae alkaloids Biochimica et Biophysica Acta. ,vol. 425, pp. 342- 348 ,(1976) , 10.1016/0005-2787(76)90261-6

A Boeyé, R Vrijsen, D A Vanden Berghe, A J Vlietinck, Lycorine: a eukaryotic termination inhibitor? Journal of Biological Chemistry. ,vol. 261, pp. 505- 507 ,(1986) , 10.1016/S0021-9258(17)36118-5

Cornel Badorff, Gil-Hwan Lee, Barry J. Lamphear, Maryann E. Martone, Kevin P. Campbell, Robert E. Rhoads, Kirk U. Knowlton, Enteroviral protease 2A cleaves dystrophin: Evidence of cytoskeletal disruption in an acquired cardiomyopathy Nature Medicine. ,vol. 5, pp. 320- 326 ,(1999) , 10.1038/6543

Peter S. Dragovich, Thomas J. Prins, Ru Zhou, Stephen E. Webber, Joseph T. Marakovits, Shella A. Fuhrman, Amy K. Patick, David A. Matthews, Caroline A. Lee, Clifford E. Ford, Benjamin J. Burke, Paul A. Rejto, Thomas F. Hendrickson, Tove Tuntland, Edward L. Brown, James W. Meador, Rose Ann Ferre, James E. V. Harr, Maha B. Kosa, Stephen T. Worland, Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 4. Incorporation of P1 lactam moieties as L-glutamine replacements. Journal of Medicinal Chemistry. ,vol. 42, pp. 1213- 1224 ,(1999) , 10.1021/JM9805384