A bioengineering study on the efficacy of a skin protectant lotion in preventing SLS-induced dermatitis.

摘要: Background/aims: This study evaluated the efficacy of a dimethicone skin protectant lotion against sodium lauryl sulfate (SLS)-induced irritant contact dermatitis (ICD) by clinical visual grading and bioengineering techniques in 12 healthy humans. Methods: The flexor aspects both forearms subjects were used as test sites. Each was duplicated to diminish variations In random order double-blind manner, two sites pretreated either with testing or its vehicle control prior SLS. Thirty minutes later, 0.2 ml 0.5% SLS polypropylene chamber applied each site. One additional site served positive (without lotion), receiving only. After 24 h exposure irritant, chambers removed. protective effect determined four parameters: scoring (VS), transepidermal water loss (TEWL), color (a* value), cutaneous blood flow volume (BFV). All assessed parameters daily for 5 days. Results: VS data showed significant decrease on comparison SLS-only treated (P<0.01) (P<0.05) (overall days). TEWL value significantly decreased (P=0.02 at day 2; P=0.008 4; P=0.014 5) (day 2, 4 5). However, BFV a* values did not show statistical difference between lotion, vehicle, sites. Conclusions: demonstrated that appropriate protection products may provide certain benefits from surfactant ICD. be prevent ICD home work environments, where irritants induce eczema.