Ion-Controlled Conformational Dynamics in the Outward-Open Transition from an Occluded State of LeuT
作者： Chunfeng Zhao , Sebastian Stolzenberg , Luis Gracia , Harel Weinstein , Sergei Noskov
DOI: 10.1016/J.BPJ.2012.07.044
关键词:
摘要: Neurotransmitter:sodium symporter (NSS) proteins are secondary Na + -driven active transporters that terminate neurotransmission by substrate uptake. Despite the availability of high-…
core.ac.uk
harvard.edu
sci-hub.se 参考文章(32)
Derek P Claxton, Matthias Quick, Lei Shi, Fernanda Delmondes De Carvalho, Harel Weinstein, Jonathan A Javitch, Hassane S Mchaourab, None, Ion/substrate-dependent conformational dynamics of a bacterial homolog of neurotransmitter:sodium symporters Nature Structural & Molecular Biology. ,vol. 17, pp. 822- 829 ,(2010) , 10.1038/NSMB.1854
Alexander D. MacKerell, Michael Feig, Charles L. Brooks, Improved treatment of the protein backbone in empirical force fields. Journal of the American Chemical Society. ,vol. 126, pp. 698- 699 ,(2004) , 10.1021/JA036959E
Matthias Quick, Hideaki Yano, Naomi R. Goldberg, Lihua Duan, Thijs Beuming, Lei Shi, Harel Weinstein, Jonathan A. Javitch, State-dependent Conformations of the Translocation Pathway in the Tyrosine Transporter Tyt1, a Novel Neurotransmitter:Sodium Symporter from Fusobacterium nucleatum Journal of Biological Chemistry. ,vol. 281, pp. 26444- 26454 ,(2006) , 10.1074/JBC.M602438200
Jayashree Srinivasan, Thomas E. Cheatham, Piotr Cieplak, Peter A. Kollman, David A. Case, Continuum Solvent Studies of the Stability of DNA, RNA, and Phosphoramidate−DNA Helices Journal of the American Chemical Society. ,vol. 120, pp. 9401- 9409 ,(1998) , 10.1021/JA981844+
David A. Caplan, Julia O. Subbotina, Sergei Yu Noskov, Molecular Mechanism of Ion-Ion and Ion-Substrate Coupling in the Na+-Dependent Leucine Transporter LeuT Biophysical Journal. ,vol. 95, pp. 4613- 4621 ,(2008) , 10.1529/BIOPHYSJ.108.139741
Mark S Sonders, Matthias Quick, Jonathan A Javitch, How did the neurotransmitter cross the bilayer? A closer view. Current Opinion in Neurobiology. ,vol. 15, pp. 296- 304 ,(2005) , 10.1016/J.CONB.2005.05.009
OLEG JARDETZKY, Simple Allosteric Model for Membrane Pumps Nature. ,vol. 211, pp. 969- 970 ,(1966) , 10.1038/211969A0
Yongfang Zhao, Matthias Quick, Lei Shi, Ernest L Mehler, Harel Weinstein, Jonathan A Javitch, Substrate-dependent proton antiport in neurotransmitter:sodium symporters Nature Chemical Biology. ,vol. 6, pp. 109- 116 ,(2010) , 10.1038/NCHEMBIO.284
Lei Shi, Harel Weinstein, Conformational Rearrangements to the Intracellular Open States of the LeuT and ApcT Transporters Are Modulated by Common Mechanisms Biophysical Journal. ,vol. 99, pp. L103- L105 ,(2010) , 10.1016/J.BPJ.2010.10.003
Yongfang Zhao, Daniel Terry, Lei Shi, Harel Weinstein, Scott C. Blanchard, Jonathan A. Javitch, Single-molecule dynamics of gating in a neurotransmitter transporter homologue Nature. ,vol. 465, pp. 188- 193 ,(2010) , 10.1038/NATURE09057