Perlecan, basal lamina proteoglycan, promotes basic fibroblast growth factor-receptor binding, mitogenesis, and angiogenesis
作者： David Aviezer , Dalit Hecht , Michal Safran , Magdalena Eisinger , Guido David
DOI: 10.1016/0092-8674(94)90031-0
关键词:
摘要: A survey of defined species cell surface and extracellular matrix heparan sulfate proteoglycans (HSPG) was performed in a search for cellular that can promote bFGF receptor binding biological activity. Of the various affinity-purified HSPGs tested, perlecan, large basement membrane HSPG, is found to induce high affinity both cells deficient HS soluble FGF receptors. Heparin-dependent mitogenic activity strongly augmented by perlecan. Monoclonal antibodies perlecan extract promoting from active HSPG preparations. In rabbit ear model vivo angiogenesis, potent inducer bFGF-mediated neovascularization. These results identify as major candidate low affinity, accessory an angiogenic modulator.
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