Fibroblasts: The arbiters of extracellular matrix remodeling.

摘要: Extracellular matrix (ECM) is the foundation on which all cells and organs converge to orchestrate normal physiological functions. In setting of pathology, ECM modified incorporate additional roles, with modifications including turnover existing deposition new ECM. The fibroblast center stage in coordinating both tissue homeostasis response disease. Understanding how fibroblasts work under conditions are activated injury or stress will provide mechanistic insight that triggers discovery therapeutic treatments for a wide range We highlight here roles cancer, lung, heart as example systems where major contributors pathology.