作者: Małgorzata Grabarczyk , Wanda Mączka , Katarzyna Wińska , Barbara Żarowska , Gabriela Maciejewska
DOI: 10.1016/J.BIOORG.2020.104250
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摘要: Abstract The aim of this research was to test the ability cultures edible fungi biotransform three bicyclic halolactones. substrates (2-chloro-, 2-bromo- and 2-iodo-4,4,6,7-tetramethyl-9-oxabicyclo[4.3.0]nonan-8-one) received by means synthesis were transformed oyster mushroom Pleurotus ostreatus mushrooms genus Armillaria mellea, Marasmius scorodonius Laetiporus sulfureus. converted hydroxyl derivatives only mushroom. Out seven strains - capable hydroxylation all with most effective conversion chlorolactone. Bromo- iodolactone a small extent. Four new chloro-hydroxylactones obtained as biotransformation products. structures products established on basis spectroscopic data. Studies antimicrobial activity performed reference pathogenic microorganisms showed that halolactones caused complete inhibition growth A. alternata F. linii strains. On other hand, able completely inhibit also C. albicans strain.