Suppressed GABAergic inhibition as a common factor in suspected etiologies of autism.

作者: John P. Hussman

DOI: 10.1023/A:1010715619091

关键词:

摘要: The primary inhibitory and excitatory amino acid neurotransmitters are gamma-aminobutyric (GABA) glutamate, respectively. Despite their pervasiveness in brain function sensory processes, the have received limited attention study of autism related developmental disabilities. While ubiquity GABA glutamate pathways CNS suggests that nearly every pathology will affect neurotransmission, verification specific impairments common to might help intensify narrow focus research.

参考文章(3)
Nuri B. Farber, John W. Newcomer, John W. Olney, The glutamate synapse in neuropsychiatric disorders. Focus on schizophrenia and Alzheimer's disease. Progress in Brain Research. ,vol. 116, pp. 421- 437 ,(1998) , 10.1016/S0079-6123(08)60453-7
E.R. Martin, M.M. Menold, C.M. Wolpert, M.P. Bass, S.L. Donnelly, S.A. Ravan, A. Zimmerman, J.R. Gilbert, J.M. Vance, L.O. Maddox, H.H. Wright, R.K. Abramson, G.R. DeLong, M.L. Cuccaro, M.A. Pericak-Vance, Analysis of linkage disequilibrium in γ-aminobutyric acid receptor subunit genes in autistic disorder American Journal of Medical Genetics. ,vol. 96, pp. 43- 48 ,(2000) , 10.1002/(SICI)1096-8628(20000207)96:1<43::AID-AJMG9>3.0.CO;2-3