Polypyrrole Hollow Microspheres as Echogenic Photothermal Agent for Ultrasound Imaging Guided Tumor Ablation

摘要: Ultrasound (US) imaging provides a valuable opportunity to administer photothermal therapy (PTT) of cancer with real-time guidance ensure proper targeting, but only few theranostic agents were developed by physically grafting near infrared (NIR)-absorbing inorganic nanomaterials ready-made ultrasound contrast (UCAs) for US guided PTT. In this paper, NIR absorbing hollow microspheres generated from polypyrrole merely using facile one-step microemulsion method. It was found that the obtained (PPyHMs) can act as an efficient agent not enhance greatly, also exhibit excellent photohyperthermic effects. The consistently sustained echo signals no less than 5 min and laser light ablated tumor completely within two weeks in presence PPyHMs. More importantly, use additional absorber substantially minimizes onetime dose agent.