Nucleoplasmin: the archetypal molecular chaperone.

作者: Dingwall C , Laskey Ra

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摘要: Nucleoplasmin was the first protein to be described as a molecular chaperone. Studies of nucleoplasmin have resulted in advances two areas cell biology. Firstly, pathway nucleosome assembly Xenopus oocytes and eggs has been elucidated is only known detail. Nucleosome represents major chaperoning function nucleoplasmin. Secondly, used elucidate transport proteins into nucleus, revealing selective entry mechanism for nuclear proteins, passage through pore complex, two-step transport. The properties functions are reviewed, together with other which related either structurally or functionally

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