Growth factor therapy in patients with partial-thickness burns: a systematic review and meta-analysis

摘要: Growth factor (GF) therapy has shown promise in treating a variety of refractory wounds. However, evidence supporting its routine use burn injury remains uncertain. We performed this systematic review and meta-analysis assessing randomised controlled trials (RCTs) to investigate efficacy safety GFs the management partial-thickness burns. Electronic searches were conducted PubMed Cochrane databases. Endpoint results analysed included wound healing scar formation. Thirteen studies comprising total 1924 participants with 2130 wounds (1131 GF receiving patients versus 999 controls) identified included, evaluating effect fibroblast growth (FGF), epidermal (EGF) granulocyte macrophage-colony stimulating (GM-CSF) on Topical application these agents significantly reduced time by 5·02 (95% confidence interval, 2·62 7·42), 3·12 CI, 1·11 5·13) 5·1 4·02 6·18) days, respectively, compared standard care alone. In addition, improvement following FGF EGF was evident terms pigmentation, pliability, height vascularity. No significant increase adverse events observed GFs. These suggested that could be an effective safe add-on for High-quality, adequately powered are needed further confirm conclusion.