Genetically modified mouse models for the study of nonalcoholic fatty liver disease
作者： Perumal Nagarajan , M Jerald Mahesh Kumar , Ramasamy Venkatesan , Subeer S Majundar , Ramesh C Juyal
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摘要: Nonalcoholic fatty liver disease (NAFLD) is associated with obesity, insulin resistance, and type 2 diabetes. NAFLD represents a large spectrum of diseases ranging from (1) (hepatic steatosis); (2) steatosis inflammation necrosis; to (3) cirrhosis. The animal models study NAFLD/nonalcoholic steatohepatitis (NASH) are extremely useful, as there still many events be elucidated in the pathology NASH. established has provided clues pathogenesis steatohepatitis, but these remain incompletely understood. different mouse can classified two groups. first one includes genetically modified (transgenic or knockout) mice that spontaneously develop disease, second acquire after dietary pharmacological manipulation. Although molecular mechanism leading development hepatic complex, may key for treatment NAFLD. Ideal NASH should closely resemble pathological characteristics observed humans. To date, no single model encompassed full human progression, they imitate particular disease. Therefore, it important researchers choose appropriate model. This review discusses various developed used research on
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Stephan Wueest, Reto A. Rapold, Eugen J. Schoenle, Daniel Konrad, Fas activation in adipocytes impairs insulin-stimulated glucose uptake by reducing Akt FEBS Letters. ,vol. 584, pp. 4187- 4192 ,(2010) , 10.1016/J.FEBSLET.2010.08.052
Tomonori Aoyama, Kenichi Ikejima, Kazuyoshi Kon, Kyoko Okumura, Kumiko Arai, Sumio Watanabe, Pioglitazone promotes survival and prevents hepatic regeneration failure after partial hepatectomy in obese and diabetic KK-Ay mice. Hepatology. ,vol. 49, pp. 1636- 1644 ,(2009) , 10.1002/HEP.22828
Matthew T Flowers, Makoto Miyazaki, Xueqing Liu, James M Ntambi, Probing the role of stearoyl-CoA desaturase–1 in hepatic insulin resistance Journal of Clinical Investigation. ,vol. 116, pp. 1478- 1481 ,(2006) , 10.1172/JCI28774
D. Auboeuf, J. Rieusset, L. Fajas, P. Vallier, V. Frering, J. P. Riou, B. Staels, J. Auwerx, M. Laville, H. Vidal, Tissue distribution and quantification of the expression of mRNAs of peroxisome proliferator-activated receptors and liver X receptor-alpha in humans: no alteration in adipose tissue of obese and NIDDM patients Diabetes. ,vol. 46, pp. 1319- 1327 ,(1997) , 10.2337/DIAB.46.8.1319
Eek Joong Park, Jun Hee Lee, Guann-Yi Yu, Guobin He, Syed Raza Ali, Ryan G. Holzer, Christoph H. Österreicher, Hiroyuki Takahashi, Michael Karin, Dietary and Genetic Obesity Promote Liver Inflammation and Tumorigenesis by Enhancing IL-6 and TNF Expression Cell. ,vol. 140, pp. 197- 208 ,(2010) , 10.1016/J.CELL.2009.12.052
Yi‐Hao Yu, Henry Ginsberg, The role of acyl-CoA:diacylglycerol acyltransferase (DGAT) in energy metabolism Annals of Medicine. ,vol. 36, pp. 252- 261 ,(2004) , 10.1080/07853890410028429
Makoto Miyazaki, Matthew T. Flowers, Harini Sampath, Kiki Chu, Carolin Otzelberger, Xueqing Liu, James M. Ntambi, Hepatic Stearoyl-CoA Desaturase-1 Deficiency Protects Mice from Carbohydrate-Induced Adiposity and Hepatic Steatosis Cell Metabolism. ,vol. 6, pp. 484- 496 ,(2007) , 10.1016/J.CMET.2007.10.014
Harry Björkbacka, Vidya V Kunjathoor, Kathryn J Moore, Stephanie Koehn, Christine M Ordija, Melinda A Lee, Terry Means, Kristen Halmen, Andrew D Luster, Douglas T Golenbock, Mason W Freeman, Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways. Nature Medicine. ,vol. 10, pp. 416- 421 ,(2004) , 10.1038/NM1008
V. B. Matthews, T. L. Allen, S. Risis, M. H. S. Chan, D. C. Henstridge, N. Watson, L. A. Zaffino, J. R. Babb, J. Boon, P. J. Meikle, J. B. Jowett, M. J. Watt, J.-O. Jansson, C. R. Bruce, M. A. Febbraio, Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistance Diabetologia. ,vol. 53, pp. 2431- 2441 ,(2010) , 10.1007/S00125-010-1865-Y
Akira Moh, Yoshiki Iwamoto, Gui-Xuan Chai, Samual Shao-min Zhang, Arihiro Kano, Derek D Yang, Wenjun Zhang, Jun Wang, Joerg J Jacoby, Bin Gao, Richard A Flavell, Xin-Yuan Fu, Role of STAT3 in liver regeneration: survival, DNA synthesis, inflammatory reaction and liver mass recovery. Laboratory Investigation. ,vol. 87, pp. 1018- 1028 ,(2007) , 10.1038/LABINVEST.3700630