Langerhans cells in Langerhans cell granulomatosis are not actively proliferating cells.

摘要: Pulmonary Langerhans cell granulomatosis (LCG), also called histiocytosis X, is a disorder of unknown etiology characterized by the presence destructive granulomas containing numerous cells (LCs). The process may be localized or multifocal, and it remains unclear whether same pathogenic mechanism involved in all forms disease. It often assumed that massive accumulation LCs at sites lesions results from abnormal proliferation these cells, although has been suggested LCG adults, least lung, could reactive initiated activated LCs. Little known, however, concerning mechanisms responsible for large numbers course disease, relative contribution recruitment local to established. To investigate this question, proportion replicating was evaluated biopsied patients with diffuse form means several histopathological techniques currently used assessment proliferation. findings demonstrate that, except proliferating nuclear antigen (PCNA), parameters measured are low They similar those renewing epithelial clearly less than neoplastic cells. These data strongly suggest not rapidly dividing population LC replication makes only minimal granuloma maintenance. Caution appears necessary use PCNA as marker growth fraction.