Antigenic and molecular characterization of recent infectious bursal disease virus isolates in China.
作者： Jue Liu , Jiao Zhou , Jimmy Kwang
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摘要: Eleven infectious bursal disease virus (IBDV) strains isolated recently from China were compared with the early classical virulent strain CJ801, chicken embryo fibroblast-adapted (CEF) variant GZ902, and attenuated vaccine BJ836, BK912, LM to discern evolutionary characteristics of IBDV in at both antigenic genetic levels. Virus neutralization (VN) assay showed that all ten very (vv) belong same subtype as strains, whereas other isolate BX could be attributed GZ902. Antigen-capture ELISA (AC-ELISA) determined by a panel monoclonal antibodies (Mabs) against further among these vv nine except for NC had no reaction neutralizing Mab B69. The SC YV non-neutralizing Mabs 2B8 2C4, respectively, whose epitopes located strains. On hand, there is alteration Sequence comparison highly variable region (HVR) VP2 proteins 98.6-100.0% identities European Asian amino acid level. For NC, SC, YV, one substitution major hydrophilic domains, indicating new are evolving. In addition, DMS residue 279N well, showing this position might not related virulence IBDV. two domains unique acids 249K 254S shared 97.3% identity VarE. Phylogenetic analysis suggests recent Chinese vvIBDVs previous still group group, which more closely F52/70 American STC than spread widely country derived Europe America
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