The pharmacokinetics of levosalbutamol: what are the clinical implications?

作者: David W. Boulton , J. Paul Fawcett

DOI: 10.2165/00003088-200140010-00003

关键词:

摘要: … than an equivalent dose of the racemic mixture. This is … of racemate remain unclear, but in the absence of clear evidence of toxicity the clinical superiority of levosalbutamol over racemic …

参考文章(105)
Denis J. Morgan, Clinical Pharmacokinetics of β-Agonists Clinical Pharmacokinectics. ,vol. 18, pp. 270- 294 ,(1990) , 10.2165/00003088-199018040-00002
G Hochhaus, H Möllmann, Pharmacokinetic/pharmacodynamic characteristics of the beta-2-agonists terbutaline, salbutamol and fenoterol. International journal of clinical pharmacology, therapy, and toxicology. ,vol. 30, pp. 342- 362 ,(1992)
Allan H. Price, Stephen P. Clissold, Salbutamol in the 1980s. A reappraisal of its clinical efficacy. Drugs. ,vol. 38, pp. 77- 122 ,(1989) , 10.2165/00003495-198938010-00004
Jonathan K. Ward, James Dow, Nigel Dallow, Paul Eynott, Stefano Milleri, G. Pietro Ventresca, Enantiomeric disposition of inhaled, intravenous and oral racemic-salbutamol in man--no evidence of enantioselective lung metabolism. British Journal of Clinical Pharmacology. ,vol. 49, pp. 15- 22 ,(2000) , 10.1046/J.1365-2125.2000.00102.X
D. S. Davies, M. E. Conolly, C. T. Dollery, C. F. George, Resistance to β‐adrenoceptor stimulants (a possible explanation for the rise in asthma deaths) British Journal of Pharmacology. ,vol. 43, pp. 389- 402 ,(1971) , 10.1111/J.1476-5381.1971.TB08070.X
Sankar Mitra, Mehmet Ugur, Ozlem Ugur, H. Maurice Goodman, John R. McCullough, Hiroshi Yamaguchi, (S)-Albuterol increases intracellular free calcium by muscarinic receptor activation and a phospholipase C-dependent mechanism in airway smooth muscle. Molecular Pharmacology. ,vol. 53, pp. 347- 354 ,(1998) , 10.1124/MOL.53.3.347
Valentin Gorboulev, Christopher Volk, Petra Arndt, Aida Akhoundova, Hermann Koepsell, Selectivity of the polyspecific cation transporter rOCT1 is changed by mutation of aspartate 475 to glutamate. Molecular Pharmacology. ,vol. 56, pp. 1254- 1261 ,(1999) , 10.1124/MOL.56.6.1254
N. Kurosawa, E. Owada, A. Kato, K. Bando, K. Ito, S. Kurosawa, Serum concentration and cardiovascular effects of salbutamol after oral and rectal administration in healthy volunteers Journal of Clinical Pharmacy and Therapeutics. ,vol. 18, pp. 103- 108 ,(1993) , 10.1111/J.1365-2710.1993.TB00575.X
David W. Boulton, J. Paul Fawcett, Determination of salbutamol enantiomers in human plasma and urine by chiral high-performance liquid chromatography. Journal of Chromatography B: Biomedical Sciences and Applications. ,vol. 672, pp. 103- 109 ,(1995) , 10.1016/0378-4347(95)00210-A