Heart rate control by carvedilol in Japanese patients with chronic atrial fibrillation: The AF Carvedilol study
作者： Hiroshi Inoue , Hirotsugu Atarashi , Ken Okumura , Takeshi Yamashita , Masayuki Fukuzawa
DOI: 10.1016/J.JJCC.2016.05.012
关键词:
摘要: Background β-Blockers are used to control heart rate (HR) in patients with atrial fibrillation (AF). However, the appropriate dosage and efficacy of carvedilol Japanese AF yet be clarified. Methods In this multicenter, randomized, double-blind study, persistent or permanent received for 6 weeks following three dosage-regimen groups: 5-mg fixed-dose (n = 42), 10-mg dose-escalation 20-mg (n = 43). To evaluate each regimen dose–response relationship, changes 24-h mean HR (mHR) on Holter electrocardiograms from baseline 2, 4, were determined as primary endpoints. The effects circadian HR, proportion achieving target clinical symptoms, adverse events also examined. Results After 2 weeks, 5 mg decreased mHR significantly [6.6 (95% CI: 5.2–8.0) beats/min, p < 0.0001]. After showed a trend dose-dependent reduction (p = 0.0638): 7.6 (5.4–9.8) group; 8.9 (6.7–11.1) 10.6 (8.4–12.8) beats/min group. There no serious related carvedilol. Conclusions In AF, at once daily demonstrated significant reduction, step-wise dose escalation 20 mg reduction.
core.ac.uk
sci-hub.se 参考文章(16)
Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) Investigators, None, A comparison of rate control and rhythm control in patients with atrial fibrillation. The New England Journal of Medicine. ,vol. 347, pp. 1825- 1833 ,(2002) , 10.1056/NEJMOA021328
J.örg Carlsson, Sinisa Miketic, J.ürgen Windeler, Alessandro Cuneo, Sebastian Haun, Stefan Micus, Sabine Walter, Ulrich Tebbe, Randomized trial of rate-control versus rhythm-control in persistent atrial fibrillation: the Strategies of Treatment of Atrial Fibrillation (STAF) study. Journal of the American College of Cardiology. ,vol. 41, pp. 1690- 1696 ,(2003) , 10.1016/S0735-1097(03)00332-2
Yoshihiro Mori, Yasuhiro Nishikawa, Tomoko Iizuka, Natsuko Zenimura, Takuyuki Matsumoto, Katsutoshi Hiramatsu, Masahiro Komiya, Artist® Tablets (Carvedilol) for Hypertensive Patients in Japan: Results of a Drug Use Survey Drugs in R & D. ,vol. 11, pp. 171- 190 ,(2011) , 10.2165/11592450-000000000-00000
Satoshi Ogawa, Takeshi Yamashita, Tsutomu Yamazaki, Yoshifusa Aizawa, Hirotsugu Atarashi, Hiroshi Inoue, Tohru Ohe, Hiroshi Ohtsu, Ken Okumura, Takao Katoh, Shiro Kamakura, Koichiro Kumagai, Yoshihisa Kurachi, Itsuo Kodama, Yukihiro Koretsune, Tetsunori Saikawa, Masayuki Sakurai, Kaoru Sugi, Toshifumi Tabuchi, Haruaki Nakaya, Toshio Nakayama, Makoto Hirai, Masahiko Fukatani, Hideo Mitamura, for the J-RHYTHM Investigators, Optimal Treatment Strategy for Patients With Paroxysmal Atrial Fibrillation Circulation. ,vol. 73, pp. 242- 248 ,(2009) , 10.1253/CIRCJ.CJ-08-0608
Authors/Task Force Members, A John Camm, Gregory YH Lip, Raffaele De Caterina, Irene Savelieva, Dan Atar, Stefan H Hohnloser, Gerhard Hindricks, Paulus Kirchhof, ESC Committee for Practice Guidelines (CPG), Jeroen J Bax, Helmut Baumgartner, Claudio Ceconi, Veronica Dean, Christi Deaton, Robert Fagard, Christian Funck-Brentano, David Hasdai, Arno Hoes, Paulus Kirchhof, Juhani Knuuti, Philippe Kolh, Theresa McDonagh, Cyril Moulin, Bogdan A Popescu, Željko Reiner, Udo Sechtem, Per Anton Sirnes, Michal Tendera, Adam Torbicki, Alec Vahanian, Stephan Windecker, Document Reviewers, Panos Vardas, Nawwar Al-Attar, Ottavio Alfieri, Annalisa Angelini, Carina Blömstrom-Lundqvist, Paolo Colonna, Johan De Sutter, Sabine Ernst, Andreas Goette, Bulent Gorenek, Robert Hatala, Hein Heidbüchel, Magnus Heldal, Steen Dalby Kristensen, Philippe Kolh, Jean-Yves Le Heuzey, Hercules Mavrakis, Lluís Mont, Pasquale Perrone Filardi, Piotr Ponikowski, Bernard Prendergast, Frans H Rutten, Ulrich Schotten, Isabelle C Van Gelder, Freek WA Verheugt, None, 2012 focused update of the ESC Guidelines for the management of atrial fibrillation: An update of the 2010 ESC Guidelines for the management of atrial fibrillation * Developed with the special contribution of the European Heart Rhythm Association Europace. ,vol. 14, pp. 1385- 1413 ,(2012) , 10.1093/EUROPACE/EUS305
Hiroshi KISHIDA, Tsutomu SAITO, Nagaharu FUKUMA, Noritake HATA, Takeshi SUZUKI, Fumio OHTSU, Evaluation of a new vasodilating beta-blocking agent, carvedilol, in exertional angina using holter monitoring. Japanese Heart Journal. ,vol. 31, pp. 449- 460 ,(1990) , 10.1536/IHJ.31.449
Takeshi Yamashita, Hiroshi Inoue, Heart rate-reducing effects of bisoprolol in Japanese patients with chronic atrial fibrillation: results of the MAIN-AF study Journal of Cardiology. ,vol. 62, pp. 50- 57 ,(2013) , 10.1016/J.JJCC.2013.02.010
Kodani, Effect of carvedilol on reduction in heart rate in patients with chronic atrial fibrillation. Journal of Clinical Medicine Research. ,vol. 5, pp. 451- 459 ,(2013) , 10.4021/JOCMR1581W
Isabelle C. Van Gelder, Hessel F. Groenveld, Harry J.G.M. Crijns, Ype S. Tuininga, Jan G.P. Tijssen, A. Marco Alings, Hans L. Hillege, Johanna A. Bergsma-Kadijk, Jan H. Cornel, Otto Kamp, Raymond Tukkie, Hans A. Bosker, Dirk J. Van Veldhuisen, Maarten P. Van den Berg, Lenient versus strict rate control in patients with atrial fibrillation. The New England Journal of Medicine. ,vol. 362, pp. 1363- 1373 ,(2010) , 10.1056/NEJMOA1001337
Writing Committee Members, Craig T January, L Samuel Wann, Joseph S Alpert, Hugh Calkins, Joseph C Cleveland Jr, Joaquin E Cigarroa, Jamie B Conti, Patrick T Ellinor, Michael D Ezekowitz, Michael E Field, Katherine T Murray, Ralph L Sacco, William G Stevenson, Patrick J Tchou, Cynthia M Tracy, Clyde W Yancy, Jeffrey L Anderson, Jonathan L Halperin, Nancy M Albert, Biykem Bozkurt, Ralph G Brindis, Mark A Creager, Lesley H Curtis, David DeMets, Robert A Guyton, Judith S Hochman, Richard J Kovacs, E Magnus Ohman, Susan J Pressler, Frank W Sellke, Win-Kuang Shen, 2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society Circulation. ,vol. 130, pp. 2071- 2104 ,(2014) , 10.1161/CIR.0000000000000041