Ubiquitin binding polypeptides

作者: Roland Hjerpe , Manuel Salvador Rodriguez Medina

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摘要: The invention relates to Tandem Ubiquitin Affinity Entities (TUBES) which are fusion polypeptides comprising at least two ubiquitin binding domains connected each other by non-naturally occurring spacer regions. TUBES capable of with high affinity and ubiquitylated therefore suitable for the purification from cellular extracts as well identification new polypeptides.

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