Role of Integrin-Related Tyrosine Kinases in Growth Control of Normal and Tumorigenic Human Mammary Epithelium.

摘要: Abstract : We are attempting to identify integrin-specific signalling events that may contribute malignant transformation in mammary epithelium. focusing on the extracellular matrix protein Iaminin-5r, which is located epithelial basement membrane. hypothesize binding of integrins laminin-5r elicits downstream help define normal phenotype cells; disruption these signals development malignancy. To date, we have established and cell lines plated differ at least three ways: cells use different integrin receptors bind laminin-5, migrate while do not, exhibit patterns tyrosine phosphate-containing proteins following laminin-5. The mediate responses been identified two types, cells, conversion from involves activation a3Beta1 integrin. Our goals for upcoming year further elucidate pathways associated with alpha 3Beta1 laminin-5r, functionally active regions responsible eliciting effects.