摘要: The disclosure provides new transmucosal and subcutaneous pharmaceutical compositions comprising 1-(4-fluoro-phenyl)-4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H,7H-pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxalin-8-yl)-butan-1-one or 1-(4-fluoro-phenyl)-4-((6bR,10aS)-2,2-d2-3-methyl-2,3,6b,9,10,10a-hexahydro-1H,7H-pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxalin-8-yl)-butan-1-one -(4-fluoro-phenyl)-4-((6bR,10aS)-1,1,2,2-d4-3-methyl-2,3,6b,9,10,10a-hexahydro-1H,7H-pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxalin-8-yl)-butan-1-one, in free base, co-crystal salt form, together with methods of making using them.
lens.org 参考文章(165)
John P. Wolfe, Stephen L. Buchwald, Michael Palucki, Palladium-catalysed synthesis of aryl ethers ,(1997)
Anthony W. Czarnik, Deuterium-enriched asenapine ,(2008)
Anthony W. Czarnik, Deuterium-enriched eplivanserin ,(2008)
John Charles Tomesch, Andrew S. Thompson, James David Beard, Hua Cheng, Wei Yao, Peng Li, Qiang Zhang, Substituted heterocycle fused gamma-carbolines synthesis ,(2008)
Albert S. Ren, Yifeng Xiong, Konrad Feichtinger, Brett Ulmann, Imidazo[1,2-a]pyridine derivatives as modulators of the 5-ht2a serotonin receptor useful for the treatment of disorders related thereto ,(2008)
John P. Wolfe, Stephen L. Buchwald, Michael Palucki, Synthesis of aryl ethers ,(1996)
Stephen Byrn, Ralph Pfeiffer, Michael Ganey, Charles Hoiberg, Guirag Poochikian, Pharmaceutical Solids: A Strategic Approach to Regulatory Considerations Pharmaceutical Research. ,vol. 12, pp. 945- 954 ,(1995) , 10.1023/A:1016241927429
John Tomesch, Lawrence P. Wennogle, Substituted heterocycle fused gamma-carbolines solid ,(2009)
Gayatri Sathyan, Sonya Seroff, Suneel K. Gupta, Iran Reyes, Julie Lee, Atul D. Ayer, Nipun Davar, Nyomi V. Yam, Methods and dosage forms for controlled delivery of paliperidone and risperidone ,(2009)
E.J. Wood, Features section: The oxford dictionary of biochemistry and molecular biology General Editors: A D Smith, S P Datta, G H Smith, P N Campbell, R Bentley and H A McKenzie. pp 740. Oxford University Press. 1997. £34.95 ISBN 0‐19‐854768‐4 Biochemical Education. ,vol. 25, pp. 251- 251 ,(1997) , 10.1016/S0307-4412(97)87558-9