Aortic vasoreactivity during a postnatal critical window of the pancreas in rats

摘要: Changes in aortic vasoreactivity during the postnatal pancreatic critical window, where insulin and glucose, which modify vasoreactivity, are elevated, were studied compared to those control metabolic syndrome (MS) rats. Twelve 21- 28-day-old rats used. To develop MS rats, male Wistar animals given 30% sucrose drinking water since weaning used when 6 months old. Glucose levels higher suckling decreased after weaning, triglycerides increased Contraction elicited by norepinephrine (NE) was stronger than KCl contraction at all ages. KCl-induced with, age being rats; it further Norepinephrine-induced from day 12 28 but stabilized 21 28; controls Vasorelaxation acetylcholine NE precontracted rings did not change neonatal period, similar lower controls. Insulin-induced increase There is a window that might predispose cardiovascular diseases adults.