Different distribution of DNA polymerases α and β in bone marrow and peripheral blood from human leukemia

摘要: An activity gel method was used to analyze the catalytic polypeptides of polymerases α and β in human acute myeloblastic lymphoblastic leukemia. A 175 kDa α-polymerase found 85% bone marrow 57% peripheral blood samples. At variance, a 40 β-polymerase 94% only 12% No difference pattern polymerase expression according type leukemia disease status. The role these enzymes their implications drug sensitivity are discussed.