Formic Acid and Acetic Acid Induce a Programmed Cell Death in Pathogenic Candida Species

摘要: Cutaneous fungal infections are common and widespread. Antifungal agents used for the treatment of these often have undesirable side effects. Furthermore, increased resistance microorganisms to antifungal drugs becomes growing problem. Accordingly, search natural compounds continues receive attention. Apoptosis is highly regulated programmed cell death. During yeast apoptosis, amino acids peptides released can stimulate regeneration human epithelium cells. Thus, detection chemical inducing apoptosis in nontoxic humans great medical relevance. The aim this study was detect compound pathogenic Candida species with lowest toxicity mammalian Five compounds—acetic acid, sodium bicarbonate, potassium carbonate, lithium acetate, formic acid—were tested evaluation activity on C. albicans, guilliermondii, lusitaniae. results showed that acetic acid at concentrations induced cells analysis revealed death accompanied by activation caspase. Minimal inhibitory carbonate bicarbonate necrosis. Toxicity test cultures has effect growth Jurkat NIH 3T3 In conclusion, our show a low concentration induces apoptosis-like minimal survivability cells, suggesting potential applications infections.