Risk of upper gastrointestinal bleeding and perforation associated with Individual non-steroidal anti-inflammatory drugs

摘要: Exposure to non-steroidal anti-inflammatory drugs (NSAIDs) is known increase substantially the risk of upper gastrointestinal bleeding and perforation (UGIB). We have carried out a population-based retrospective case-control study assess variation in associated with various individual NSAIDs, adjustment for features use other independent factors. The sample comprised 1457 cases UGIB 10,000 control subjects identified from general practitioners' computerised records UK. adjusted estimate relative current NSAID was 4.7 (95% CI 3.8-5.7). Previous single most important predictor (relative 13.5 [10.3-17.7]). For all NSAIDs together, greater high doses than low (7.0 [5.2-9.6] vs 2.6 [1.8-3.8]). estimates varied widely. Users azapropazone (23.4 [6.9-79.5]) piroxicam (18.0 [8.2-39.6]) had highest among studied. All sufficient data analysis (ibuprofen, naproxen, diclofenac, ketoprofen, indomethacin) risks similar that overall use. NSAIDS should be used cautiously patients who factors UGIB; these include advanced age, smoking, history peptic ulcer, oral corticosteroids or anticoagulants.