Loss of SATB1 Induces a p21 Dependent Cellular Senescence Phenotype in Dopaminergic Neurons
作者： Markus Riessland , Benjamin Kolisnyk , Tae Wan Kim , Jia Cheng , Jason Ni
DOI: 10.1101/452243
关键词:
摘要: Abstract Cellular senescence is a mechanism used by mitotic cells to prevent uncontrolled cell division. As senescent persist in tissues, they cause local inflammation and are harmful surrounding cells, contributing aging. Generally, neurodegenerative diseases, such as Parkinson‘s, disorders of The contribution cellular neurodegeneration still unclear. SATB1 DNA binding protein associated with Parkinson’s disease. We report that prevents post-mitotic dopaminergic neurons. Loss causes activation transcriptional program dopamine neurons, both human stem cell-derived neurons mice. observed phenotypes which central knockout vitro vivo. Moreover, we found directly represses expression the pro-senescence factor, p21, Our data implicate factor pathology
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