Hollow fiber solvent extraction of pharmaceutical products: A case study
作者： R. Prasad , K.K. Sirkar
DOI: 10.1016/S0376-7388(00)83078-1
关键词:
摘要: Abstract Dispersion-free solvent extraction using Celgard® microporous hydrophobic hollow fibers and flat membranes has been utilized for extraction/purification of fermentation-based pharmaceutical products. Extraction as well back studied a pH swing procedure. Problems emulsion formation, inherent in current processes, have avoided to obtain stable dispersion-free operation. Very high solute recoveries mass transfer rates obtained the fiber devices. Modular plant design series-parallel arrangement this type extractors cost existing dispersion-based devices indicate that these novel can compete effectively with commercial extractors.
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sci-hub.se 参考文章(17)
Lyman C. Craig, IDENTIFICATION OF SMALL AMOUNTS OF ORGANIC COMPOUNDS BY DISTRIBUTION STUDIES. APPLICATION TO ATABRINE Journal of Biological Chemistry. ,vol. 150, pp. 33- 45 ,(1943) , 10.1016/S0021-9258(18)51248-5
R. Prasad, K. K. Sirkar, Dispersion‐free solvent extraction with microporous hollow‐fiber modules Aiche Journal. ,vol. 34, pp. 177- 188 ,(1988) , 10.1002/AIC.690340202
Paul R. Alexander, Robert W. Callahan, Liquid-liquid extraction and stripping of gold with microporous hollow fibers Journal of Membrane Science. ,vol. 35, pp. 57- 71 ,(1987) , 10.1016/S0376-7388(00)80922-9
R. Prasad, A. Kiani, R.R. Bhave, K.K. Sirkar, Further studies on solvent extraction with immobilized interfaces in a microporous hydrophobic membrane Journal of Membrane Science. ,vol. 26, pp. 79- 97 ,(1986) , 10.1016/S0376-7388(00)80114-3
Patricia D. Mackenzie, C. Judson King, Combined solvent extraction and stripping for removal and isolation of ammonia from sour waters Industrial & Engineering Chemistry Process Design and Development. ,vol. 24, pp. 1192- 1200 ,(1985) , 10.1021/I200031A050
Paul R. Bienkowski, Douglas D. Lee, Charles H. Byers, Evaluation of separation and purification processes in the antibiotic industry. Scientific note. Applied Biochemistry and Biotechnology. ,vol. 18, pp. 261- 273 ,(1988) , 10.1007/BF02930830
Byoung-Sik Kim, Peter Harriott, Critical entry pressure for liquids in hydrophobic membranes Journal of Colloid and Interface Science. ,vol. 115, pp. 1- 8 ,(1987) , 10.1016/0021-9797(87)90002-6
Ravi Prasad, K. K. Sirkar, Solvent extraction with microporous hydrophilic and composite membranes Aiche Journal. ,vol. 33, pp. 1057- 1066 ,(1987) , 10.1002/AIC.690330702
Ming-Chien Yang, E. L. Cussler, Designing hollow‐fiber contactors Aiche Journal. ,vol. 32, pp. 1910- 1916 ,(1986) , 10.1002/AIC.690321117
Ronald L. Fournier, Mathematical model of microporous hollow‐fiber membrane extractive fermentor Biotechnology and Bioengineering. ,vol. 31, pp. 235- 239 ,(1988) , 10.1002/BIT.260310309