Enantioselective Synthesis of (+)-α-Conhydrine and (-)-Sedamine by L-Proline-Catalysed α-Aminooxylation
作者： Tanveer Mahamadali Shaikh , Arumugam Sudalai
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摘要: An efficient organocatalytic approach to the enantioslective synthesis of two important piperidine alkaloids, namely (+)-α-conhydrine (98 % ee) and (-)-sedamine (95 ee), by L -proline-catalysed α-aminooxylation aldehydes has been developed. The strategy involves an intramolecular cyclization construct core.
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