Cilostazol protects mice against myocardium ischemic/reperfusion injury by activating a PPARγ/JAK2/STAT3 pathway.

作者: Jiangjin Li , Xiaoli Xiang , Xiaoxuan Gong , Yafei Shi , Jing Yang

DOI: 10.1016/J.BIOPHA.2017.07.143

关键词:

摘要: … Myocardial ischemia/reperfusion (MIR) injury causes severe arrhythmias and a high lethality. The present study is designed to investigate the effect of cilostazol on MIR injury and the …

参考文章(51)
Takayuki Morikawa, Katsuji Hattori, Mayumi Kajimura, Makoto Suematsu, The Effects of Cilostazol on Tissue Oxygenation upon an Ischemic-reperfusion Injury in the Mouse Cerebrum Advances in Experimental Medicine and Biology. ,vol. 662, pp. 89- 94 ,(2010) , 10.1007/978-1-4419-1241-1_12
Yutaka Matsumoto, Keiko Marukawa, Hiromi Okumura, Tomoya Adachi, Takeshi Tani, Yukio Kimura, Comparative study of antiplatelet drugs in vitro: distinct effects of cAMP-elevating drugs and GPIIb/IIIa antagonists on thrombin-induced platelet responses. Thrombosis Research. ,vol. 95, pp. 19- 29 ,(1999) , 10.1016/S0049-3848(98)00189-3
Peng Yu, Jing Zhang, Shuchun Yu, Zhenzhong Luo, Fuzhou Hua, Linhui Yuan, Zhidong Zhou, Qin Liu, Xiaohong Du, Sisi Chen, Lieliang Zhang, Guohai Xu, Protective Effect of Sevoflurane Postconditioning against Cardiac Ischemia/Reperfusion Injury via Ameliorating Mitochondrial Impairment, Oxidative Stress and Rescuing Autophagic Clearance. PLOS ONE. ,vol. 10, ,(2015) , 10.1371/JOURNAL.PONE.0134666
Jiefu Lin, Tingting Wang, Yalan Li, Mengxia Wang, Haobo Li, Michael G. Irwin, Zhengyuan Xia, N-Acetylcysteine Restores Sevoflurane Postconditioning Cardioprotection against Myocardial Ischemia-Reperfusion Injury in Diabetic Rats Experimental Diabetes Research. ,vol. 2016, pp. 9213034- 9213034 ,(2016) , 10.1155/2016/9213034
Yushan Bai, Muqier , Hiroya Murakami, Masamitsu Iwasa, Shohei Sumi, Yoshihisa Yamada, Hiroaki Ushikoshi, Takuma Aoyama, Kazuhiko Nishigaki, Genzou Takemura, Bunji Uno, Shinya Minatoguchi, Cilostazol protects the heart against ischaemia reperfusion injury in a rabbit model of myocardial infarction: focus on adenosine, nitric oxide and mitochondrial ATP-sensitive potassium channels. Clinical and Experimental Pharmacology and Physiology. ,vol. 38, pp. 658- 665 ,(2011) , 10.1111/J.1440-1681.2011.05550.X
Mohammed R. Moussavian, Preconditioning by Cilostazol Protects against Cold Hepatic Ischemia-Reperfusion Injury Annals of Transplantation. ,vol. 20, pp. 160- 168 ,(2015) , 10.12659/AOT.893031
Jian Yang, Hong Jiang, Jun Yang, Jia-Wang Ding, Li-Hua Chen, Song Li, Xiao-Dong Zhang, None, Valsartan preconditioning protects against myocardial ischemia–reperfusion injury through TLR4/NF-κB signaling pathway Molecular and Cellular Biochemistry. ,vol. 330, pp. 39- 46 ,(2009) , 10.1007/S11010-009-0098-1
Lazaros A. Nikolaidis, Sunil Mankad, George G. Sokos, Glen Miske, Ankur Shah, Dariush Elahi, Richard P. Shannon, Effects of Glucagon-Like Peptide-1 in Patients With Acute Myocardial Infarction and Left Ventricular Dysfunction After Successful Reperfusion Circulation. ,vol. 109, pp. 962- 965 ,(2004) , 10.1161/01.CIR.0000120505.91348.58
Chang-lin Zhai, Mei-qi Zhang, Yun Zhang, Hong-xia Xu, Jing-min Wang, Gui-peng An, Yuan-yuan Wang, Li Li, Glycyrrhizin protects rat heart against ischemia-reperfusion injury through blockade of HMGB1-dependent phospho-JNK/Bax pathway. Acta Pharmacologica Sinica. ,vol. 33, pp. 1477- 1487 ,(2012) , 10.1038/APS.2012.112
He Li, Wei Lu, Wei-Wei Cai, Pei-Jian Wang, Ning Zhang, Chang-Ping Yu, Dong-Liang Wang, Bai-Cheng Liu, Wei Sun, Telmisartan attenuates monocrotaline-induced pulmonary artery endothelial dysfunction through a PPAR gamma-dependent PI3K/Akt/eNOS pathway Pulmonary Pharmacology & Therapeutics. ,vol. 28, pp. 17- 24 ,(2014) , 10.1016/J.PUPT.2013.11.003