The role of cerebral blood flow gradient in peritumoral edema for differentiation of glioblastomas from solitary metastatic lesions

摘要: // Lin 1 , Yunjing Xue Qing Duan Bin Sun Hailong Xinming Huang and Xiaodan Chen 2 Department of Radiology, Union Hospital Fujian Medical University, Fuzhou, Fujian, China Fujian Provincial Cancer Hospital, Correspondence to: Xue, email: Keywords : three-dimensional arterial spin labeling, cerebral blood flow, perfusion, glioblastoma, metastasis Received May 04, 2016 Accepted September 02, Published 15, Abstract Objective: Differentiation glioblastomas from solitary brain metastases using conventional MRI remains an important unsolved problem. In this study, we introduced the conception flow (CBF) gradient in peritumoral edema—the difference CBF values proximity enhancing tumor to normal-appearing white matter, investigated contribution perfusion metrics on discrimination glioblastoma a metastatic lesion. Materials Methods: Fifty-two consecutive patients with or lesion underwent labeling (3D-ASL) before surgical resection. The were measured edema (near: G1; Intermediate: G2; Far: G3). was calculated as subtractions G1 –CBF G3 – G2 . A receiver operating characteristic (ROC) curve analysis used seek for best cutoff value permitting between these two tumors. Results: absolute/related regions significantly higher than those metastases( P < 0.038). ROC reveals, 1.92 ml/100g generated combination sensitivity (92.86%) specificity (100.00%) distinguishing metastasis. Conclusion: appears be more promising ASL differentiating high grade glioma