NRF2 and p53: Januses in cancer?

摘要: The transcription factor nuclear (erythroid-derived 2)-like 2, also known as NFE2L2 or NRF2, is a master regulator of the anti-oxidative stress response and positively controls expression battery proteins enzymes implicated in detoxification glutathione generation. Although its detoxifying activity important cancer prevention, it has recently been shown that cells exploit protective functions to thrive resist chemotherapy. NRF2 was pentose phosphate pathway glutaminolysis, which promotes purine synthesis for supporting rapid proliferation providing protection. Evidence obtained from patients cell lines suggest highly active variety human cancers associated with aggressiveness. p53 tumor suppressor an metabolic program glutaminolysis. Here we will discuss similarities between review evidence might be exploited by gain protection against oxidative stress, case NRF2. We findings co-regulation these factors propose possible therapeutic strategies can used treatment harbor WT express high levels