Androgens and Antiandrogens

摘要: The role of androgens in women's health has been generally neglected. Currently available assays are lacking sensitivity and reliability at the lower ranges. Circulating as prohormones for other steroids (e.g., androgens) have an ubiquitous on diverse physiological behavioral systems. Clinical assessment both androgen production availability can be achieved by measurement two or three essential values. These include either total T sex-hormone binding globulin (SHBG), free SHBG, T. testosterone index (total T/SHBG) correlates well with bioavailable used a substitute. DHEA-S is most useful measure adrenal women. Androgen insufficiency women not specific consequence natural menopause, but may occur secondarily to age-related decline ovarian production. Since estrogen effects also strongly linked mood, psychological well-being, sexual function women, diagnosis should only made who adequately estrogenized. Before initiating trial replacement therapy, comprehensive clinical performed all cases. Approved therapy yet countries treatment female dysfunction. This would supplements DHEA. Several new progestins synthesized last decade. Dienogest hybrid progestin that derived from pregnane estrane groups 17alpha-cyanomethyl radical; drospirenone spirolactone. Somehow, molecules demonstrated antiandrogenic properties. Cyproterone acetate (CPA) potent progestin, followed dienogest, drosperinone, chlormadinone acetate. Nomegestrol medrogestone exert some properties similar potency. While act positively libido doses HRT do appear negative effect. Progestins varying pharmacological associated different adverse effects. avoid many androgenic side related testosterone-derived progestins. They potential counteracting beneficial effects, example, cardiovascular system mental tone.