High Prevalence of Vitamin D Deficiency in Native versus Migrant Mothers and Newborns in the North of Italy: A Call to Act with a Stronger Prevention Program

摘要: Background Vitamin D status during pregnancy is related to neonatal vitamin status. Vitamin deficiency has been associated with an increased risk of rickets in children and osteomalacia adults. Aim this study was investigate 25OHD levels maternal serum blood spots native migrant populations living Novara (North Italy, 45°N latitude). Methods Findings We carried out a cross sectional from April 1st 2012 March 30th 2013, tertiary Care Center. Maternal samples after delivery newborns' were analyzed for 533 pairs. country origin, skin phototype, dietary intake supplementation recorded. Multivariate regression analysis, showed link between (R-square:0.664). Severely deficient values (<25 nmol/L) found 38% Italian 76.2% migrant’s newborns (p <0.0001), 18% 48,4% mothers <0.0001) while (≥25 <50 shown 40.1% 21.7% 43.6% 41.3% <0.0001). had higher (34.4±19.2 44.9±21.2nmol/L) than migrants (17.7±13.7 29.7±16.5nmol/L; p<0.0001). A linear decrease increasing pigmentation (phototype I 42.1 ±18.2 vs phototype VI 17.9±10.1 nmol/l; resulted both their (p<0.0001). Conclusions insufficiency frequent especially among migrants. prevention program Piedmont should urgently be considered people identified as being at closely monitored. taken into account when considering preventative health care policy.