Vitamin D Regulation of Energy Metabolism in Cancer

摘要: Vitamin D exerts anti-cancer effects in recent clinical trials and preclinical models. The actions of vitamin are primarily mediated through its hormonal form, 1,25-dihydroxyvitamin (1,25(OH)2 D). Previous literature describing vitro studies has predominantly focused on the anti-tumourigenic hormone, such as proliferation apoptosis. However, evidence identified 1,25(OH)2 a regulator energy metabolism cancer cells, where requirements for specific sources at different stages progression dramatically altered. suggests that regulates metabolism, including glucose, glutamine lipid during progression, well oxidative stress protection, it is closely associated with metabolism. Mechanisms involved regulation an emerging area which may inhibit multiple progression.