Perinatal Exposure to Lead: Reduction in Alterations of Brain Mitochondrial Antioxidant System with Calcium Supplement
作者： Chand Basha Davuljigari , Rajarami Reddy Gottipolu
DOI: 10.1007/S12011-014-0112-7
关键词:
摘要: Lead (Pb) is a potent neurotoxicant that causes several neurochemical and behavioral alterations. Previous studies showed the gestational lactational exposure to Pb reduces cholinergic aminergic systems, behavior of rats. The present study was designed examine protective effects calcium supplementation against Pb-induced oxidative stress in cerebellum hippocampus brain at postnatal day (PND) 21, PND 28, 35, 60. Pregnant rats were exposed 0.2 % (Pb acetate drinking water) from 6 (GD 6) pups through maternal milk till weaning (PND 21). We found activity serum ceruloplasmin oxidase (Cp), mitochondrial manganese superoxide dismutase (Mn-SOD), copper zinc (Cu/Zn-SOD), glutathione peroxidase (GPx), catalase (CAT), xanthine (XO) enzyme activities decreased, whereas malondialdehyde (MDA) levels increased Pb-exposed These changes more prominent 35 greater compared cerebellum. Among activities, Mn-SOD Cu/Zn-SOD maximum decrease GPx, CAT, XO, Cp. Furthermore, 0.02 % together with significantly reversed alterations MDA levels. In conclusion, these data suggest early life induce antioxidant system regions which remain for long even after has stopped. Calcium may potentially be beneficial treating toxicity developing rat brain.
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