Progesterone Resistance, Aromatase, and Inflammation: The Important Relationships Between Hormones and Inflammation

摘要: Endometriosis is a complex gynecologic disorder in which alterations of specific biological processes involving both the endocrine and immune systems have been identified. Recently, reduced endometrial responsiveness to progesterone has suggested as crucial element pathophysiology disease but it unclear whether this sensitivity steroid involved induction or simply consequence condition. Indeed, endometriosis associated with local systemic inflammatory process that strongly inter-related activity, mutually interact loop influences development maintenance. The link between prostaglandin E2 (PGE2), aromatase estrogen synthesis represents paradigm loop. A better understanding interaction should enable researchers develop targeted therapeutics may limit self-supporting pathologic