Nuclear and Cytoplasmic Glycosylation

摘要: abstract O-GlcNAcylation is a form of cytoplasmic and nuclear glycosylation that found on many diverse proteins the cell including RNA polymerase II its associated transcription factors, cytoskeletal proteins, nucleoporins, viral heat shock tumor suppressors, oncogenes. It involves attachment single, unmodified N -acetylglucosaminyl residue O-glycosidically linked to hydroxyl groups serine threonine moieties proteins. highly abundant dynamic posttranslational modification appears modulate function in manner similar phosphorylation. All O -GlcNAc-containing are phosphoproteins involved formation multimeric complexes, suggesting -GlcNAc may play role mediating protein-protein interactions. sites resemble phosphorylation cases two modifications mutually exclusive; therefore, act as an antagonist help mediate essential functions cell.