Electrochemical sensor based on gold nanoparticles fabricated molecularly imprinted polymer film at chitosan-platinum nanoparticles/graphene-gold nanoparticles double nanocomposites modified electrode for detection of erythromycin.

摘要: Abstract A molecularly imprinted electrochemical sensor was fabricated based on gold electrode decorated by chitosan–platinum nanoparticles (CS–PtNPs) and graphene–gold (GR–AuNPs) nanocomposites for convenient sensitive determination of erythromycin. The synergistic effects CS–PtNPs GR–AuNPs improved the response sensitivity sensor. polymers (MIPs) were prepared HAuCl 4 , 2-mercaptonicotinic acid (MNA) Erythromycin MNA used as template molecule functional monomer, respectively. They first assembled surface GR–AuNPs/CS–PtNPs/gold formation Au–S bonds hydrogen-bonding interactions. Then MIPs formed electropolymerization characterized cyclic voltammetry (CV), scanning electron microscope (SEM), UV–visible (UV–vis) absorption speactra amperometry. linear range from 7.0×10 −8  mol/L–9.0×10 −5  mol/L, with limit detection (LOD) 2.3×10  mol/L ( S / N =3). showed high selectivity, excellent stability good reproducibility erythromycin, it successfully applied to erythromycin in real spiked samples.