Burden of endemic health-care-associated infection in developing countries: systematic review and meta-analysis

摘要: Summary Background Health-care-associated infection is the most frequent result of unsafe patient care worldwide, but few data are available from developing world. We aimed to assess epidemiology endemic health-care-associated in countries. Methods searched electronic databases and reference lists relevant papers for articles published 1995–2008. Studies containing full or partial countries related prevalence incidence—including overall major sites, their microbiological cause—were selected. classified studies as low-quality high-quality according predefined criteria. Data were pooled analysis. Findings Of 271 selected articles, 220 included final Limited retrieved some regions many not represented. 118 (54%) low quality. In general, frequencies reported greater than those studies. Prevalence (pooled studies, 15·5 per 100 patients [95% CI 12·6–18·9]) was much higher proportions Europe USA. Pooled density adult intensive-care units 47·9 1000 patient-days (95% 36·7–59·1), at least three times high densities Surgical-site leading hospitals cumulative incidence 5·6 surgical procedures), strikingly recorded developed Gram-negative bacilli represented common nosocomial isolates. Apart meticillin resistance, noted 158 290 Staphylococcus aureus isolates (in eight studies), very antimicrobial resistance. Interpretation The burden high. Our findings indicate a need improve surveillance infection-control practices. Funding World Health Organization.