Treatment of Paraphilic Disorders in Sexual Offenders or Men With a Risk of Sexual Offending With Luteinizing Hormone-Releasing Hormone Agonists: An Updated Systematic Review.

摘要: Abstract Background Different pharmacologic agents are used in the treatment of paraphilic disorders sexual offenders or men with a risk offending, luteinizing hormone-releasing hormone (LHRH) agonists being introduced more recently to regimens. Aim To summarize relevant literature concerning LHRH agonist and update previously published systematic review by Briken et al (J Clin Psychiatry 2003;64:890–897). Methods The PubMed Google Scholar databases were searched for from January 2003 through October 2017 using following key words: agonists, GnRH antiandrogens AND paraphilia, pedophilia, sex offenders. Outcomes Evaluation effectiveness side effects Results After screening duplicates applying specific selection criteria, search yielded 24 eligible studies reporting on sample 256 patients. There is increasing evidence that effective than steroidal lowering thoughts behaviors. Current research also based methods might be less susceptible faking (eg, eye-tracking, brain imaging, viewing-time measures). Side occurring most frequently fatigue, hot flashes, depressive mood, weight gain, high blood pressure, diabetes, gynecomastia, loss erectile function, bone mineral density. Clinical Implications Although seem drugs fantasies behaviors, they should reserved patients disorder highest offending because their extensive effects. Strengths Limitations This considers all types disorders, thereby providing complete overview current state research. However, case reports observational randomized controlled clinical trials have not been conducted published. Conclusions useful when combined psychotherapy offending. throughout treatment, close monitoring needed ethical concerns must always kept mind. Turner D, P. Treatment Paraphilic Disorders Sexual Offenders Men With Risk Offending Luteinizing Hormone-Releasing Hormone Agonists: An Updated Systematic Review. J Sex Med 2018;15:77–93.