A General Amino Acid Synthesis Enabled by Innate Radical Cross-Coupling.
作者： Shengyang Ni , Alberto F. Garrido-Castro , Rohan R. Merchant , Justine N. de Gruyter , Daniel C. Schmitt
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摘要: The direct union of primary, secondary, and tertiary carboxylic acids with a chiral glyoxylate-derived sulfinimine provides rapid access into variety enantiomerically pure α-amino (>85 examples). Characterized by operational simplicity, this radical-based reaction enables the modular assembly exotic acids, including both unprecedented structures those established industrial value. described method performs well in high-throughput library synthesis, has already been implemented three distinct medicinal chemistry campaigns.
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