Serum retinyl esters are not associated with biochemical markers of liver dysfunction in adult participants in the third National Health and Nutrition Examination Survey (NHANES III), 1988–1994

摘要: Background: Serum retinyl ester concentrations are elevated in hypervitaminosis A. It was suggested that esters > 10% of total serum vitamin A indicate potential hypervitaminosis, but this cutoff derived from small clinical samples may not be representative the general population. Objective: We sought to examine distribution and associations between biochemical markers liver dysfunction a nationally sample. Design: assessed 5 indexes by using multivariate linear multiple logistic regression techniques controlling for age, sex, use supplements containing A, alcohol consumption, smoking status, exogenous estrogens 6547 adults aged ≥ 18 y third National Health Nutrition Examination Survey (NHANES III), 1988-1994. Results: Thirty-seven percent sample had 15% found no 1) any variable (multiple regression) or 2) risk having variables above reference range regression). did find value with statistically significant sensitivity specificity predicting increases dysfunction. Conclusions: The prevalence concentration NHANES III substantially higher than expected were associated abnormal function.