Regulation of mRNA Production by the Adenoviral E1B 55-kDa and E4 Orf6 Proteins

摘要: The E1B 55-kDa and E4 Orf6 proteins of human subgroup C adenoviruses both counter host cell defenses mediated by the cellular p53 protein regulate viral late gene expression. A complex containing two has been implicated in induction selective export mRNAs from nucleus to cytoplasm, with concomitant inhibition majority newly synthesized mRNAs. molecular mechanisms which these subvert pathways nuclear are not yet clear. Here, we review recent efforts identify biochemical functions required for regulation mRNA export, several difficulties discrepancies that have encountered studies proteins, evidence indicating reorganization infected production at specific intra-nuclear sites important determinants cells. In our view, it is possible propose a coherent model ElB proteins. However, should now be address questions about roles potentially relevant properties