Activation of the Endothelium-Derived Relaxing Factor System in Acute Unilateral Ureteral Obstruction
作者： David A. Schulsinger , Frederick A. Gulmi , Shyan-Yih Chou , Unni M.M. Mooppan , Hong Kim
DOI: 10.1016/S0022-5347(01)64908-5
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摘要: AbstractPurpose: To investigate the effects of L-arginine, a substrate for nitric oxide (NO) synthase, on renal hemodynamics in acute ureteral obstruction (UUO).Materials and Methods: Renal blood flow (RBF) pressure (UP) were measured anesthetized dogs with or without UUO.Results: In 9 (Group 1), RBF was 212 +/− 13 ml./min. before UUO, significantly increased to 302 18 268 at 90 140 min. post-UUO, respectively, associated marked increase UP from 3 1 mm. Hg 73 5 83 2 respectively. 6 2) prostaglandin synthesis inhibited meclofenamate (5 mg./kg., i.v.). After did not change markedly attenuated when compared Group 1, as rose only 27 34 4 pre-treated meclofenamate, L-arginine infused into artery mg./kg./min. m...
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