Progesterone administration in vivo stimulates release of luteinizing hormone-releasing hormone in vitro

摘要: The release of luteinizing hormone-releasing hormone (LHRH) from tissue the mediobasal hypothalamic-anterior hypothalamic-preoptic area prepuberal female rats was measured in a perfusion system. Measurements were also made concentrations LHRH these fragments and serum obtained when killed. Four groups immature studied: intact, ovariectomized, ovariectomized implanted with estradiol-containing capsules, primed estradiol injected progesterone. animals significantly less than that intact females not modified received estradiol. However, there four- to fivefold increase they killed 6 hours after an injection varied among time day interactions hormone, gonadal steroids, photoperiod seem set appropriate conditions for neural processes triggering complete normal hormone.