Structure-Based Modeling of Histone Deacetylases Inhibitors
作者： Rino Ragno
DOI: 10.1016/B978-0-12-802808-7.00006-X
关键词:
摘要: In this chapter, the application of various structure-based modeling techniques and protocols to HDAC enzymes are reviewed. This chapter focuses on drug discovery approaches histone deacetylase (HDAC) inhibitors (HDACi) that were applied by Rome Center for Molecular Design lab. covers mainly zinc-based HDACi, although some studies NAD-based (sirtuin) also included at end chapter.
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