Regulatory T cells: back to the future.

摘要: Regulatory T cells seem to represent the resurrection of old suppressor cells. Although a different phenotype, regulatory are able suppress many cell mediated immune responses. While most basic knowledge about these is derived from animal studies, recent identification in humans has further attributed their characterisation by vitro analysis. Results obtained have led broad speculations therapeutic potential interference with This review an introduction world and contains historical overview respect A distinction made between naturally occurring (nT(reg)), which require cell-cell contact for suppression, inducible (iT(reg)), predominantly mediate suppression via cytokine dependent pathways. only limited studies on human disease available today, possible clinical applications discussed light other side coin, i.e. danger interfering homeostatic mechanisms system.