Epigenetic Programming of Synthesis, Release, and/or Receptor Expression of Common Mediators Participating in the Risk/Resilience for Comorbid Stress-Related Disorders and Coronary Artery Disease

摘要: Corticotrophin releasing factor, vasopressin, oxytocin, natriuretic hormones, angiotensin, neuregulins, some purinergic substances, and cytokines contribute to the long-term modulation restructuring of cardiovascular regulation networks and, at same time, have relevance in situations comorbid abnormal stress responses. The synthesis, release, receptor expression these mediators seem be under epigenetic control since early stages life, possibly underlying comorbidity coronary artery disease (CAD) stress-related disorders (SRD). exposure environmental conditions, such as stress, during critical periods life may cause programming modifying development pathways that lead stable long-lasting alterations functioning adulthood, determining risk or resilience CAD SRD. However, contrast genetic information, marks dynamically altered throughout lifespan. Therefore, epigenetics reprogrammed if individual accepts challenge undertake changes their lifestyle. Alternatively, remain fixed and/or even inherited next generation. In this paper, we analyze common neuroendocrine functions SRD summarize evidence indicating they are put forward theoretical hypothesis diseases might epigenetically programmed modified over lifespan individual.